Before you submit your manuscript, here are some points you can check for yourself:

Title: Is the title provocative? Aside from your cover letter, the title is the first thing about your manuscript that the editor will see. A dull, unprovocative title doesn’t bode well for your style. The editor that bought my non-fiction book, Hats Are for Watering Horses, told me that she fell in love with the title immediately. “Only a poor manuscript would have prevented me from my instant decision to buy it based on the title alone.”
Put as much thought into your title as you do in your plot. List the possibilities, and wait until you are satisfied with your manuscript before you make your final selection. It should give us the essence without telescoping the story, i.e. “Suzie Goes Shopping.” Perhaps something like “A Bag of Surprises” would tempt the reader better.

Introduction: Is the opening sentence a strong one? Do the first few sentences or paragraphs let the reader know who, what, when, where, and why of the story? Does the story begin too far back? Start with the moment the situation changes. We don’t need to get up, bathe, brush teeth, dress, eat breakfast, pack, etc. to go to Grandma’s. Start with the arrival, or better yet, start with the first time the protagonist stomps off angrily.

Character: Is your main character [protagonist] the most important one in the story? Is he/she interesting, likable and well-rounded [believable]? Is he/she the correct age for your readers? Can your readers visualize the protagonist through his/her actions, description and dialogue? Would the story be the same even if he/she were not in it? You need to rethink your cast of characters.]
Does the protagonist have a real problem that is appropriate for his/her age? Is it one the readers can recognize? Can he/she solve the problem without help? Have you kept to a single viewpoint? Review the manuscript to be sure that ONLY your protagonist’s thoughts and senses are overt. Show all other characters objectively, i.e., what you observe within your main character’s sight and earshot. Verbs like “thought, heard, saw, etc.” are for your main character only.

Style: Have you used strong action verbs? People don’t just walk. They amble, pace, totter, or stomp, according to their mood. Are the tone, style, and general feeling, portrayed in keeping with the time and setting? Does it move quickly toward the climax? Is the ending satisfactory with no loose ends, pat endings or coincidence? Did you omit obvious and extraneous explanations? Do the last several sentences wrap up logically? Does it leave you with a feeling that “justice” or that there is at least hope, if not a happy ending? Is it clear in unhappy endings that it was the character’s choice?
Is your dialogue natural? Does it move the plot forward? Does the story flow smoothly between scenes? [A simple “Back home,” or “Later” moves the protagonist from school to home. We don’t need the bus ride.] Have you kept the moral from hanging out there in plain sight? [SHOW the change in your character; don’t just tell us.]
Did you find weak spots that need to be deleted or strengthening? Are there gaps that need transitions or explanations? Is there variety in sentence structure? Do you have passive sentences [“started to,” “began to,” “was walking.” Did you eliminate verbatim greetings: “Hello. How are you? I am fine,” etc.]

Length: Editors reject beautifully written stories because they are longer than the magazines stated length allowance. Even books have limits for financial reasons. Check out the magazine markets for limits. No story truly suffers from cutting, and I’ve yet to see one bleed. Go through your story. Are there whole scenes that can be cut and the story still make sense? Is it still too long? Check for whole paragraphs, and then for sentences within the saved paragraphs. Look for unnecessary words within the saved sentences [So, well, really, very, just, even, at all, certainly, definitely, exactly, anyway, some, all of a sudden, there is, it is, forms of to be.]

There is a time to let go. When you have done the best you can at that moment, follow the publisher’s guidelines for submissions. Not many publishers have the courtesy of saying “no thanks” anymore. Mark your calendar for when you should move on to the next. Put it out of your mind and start a new story. If the recipient publisher lacks the foresight to purchase your baby, take the opportunity to reread your manuscript with a fresh eye. Chances are, you’ll find a few things you want to change before sending it to the next. That’s a good indication that you are growing as a writer. Celebrate!